Victory for the Three Lions will secure promotion back to the top tier of the Nations League and confidence in the camp is high after Thursday’s 3-0 win in Greece.
Lee Carsley will take charge of England for the last time as interim head coach before Thomas Tuchel takes over in January.
Harry Kane will return to lead the England attack after starting on the bench against Greece.
Ireland come into the game off the back of a 1-0 win over Finland.
Here’s all you need to know to know about where to watch the game…
How to watch England vs Republic of Ireland
TV channel: The game will be broadcast for free on ITV 1. Coverage starts at 4pm GMT ahead of a 5pm kick-off at Wembley.
Live stream: ITVX, which is free with a subscription, will offer a live stream.