Kate Lanigan and Ryan Griffin fought back from five down after 10 holes to take Mary Mulcahy and Jackson Van Paris to the 18th but came up empty-handed as the Americans closed with a birdie to win two-up.
International coach Barry Fennelly was gutted for the Irish pair but pleased overall to head into the singles with the scores tied.
“To be honest, I think it’s a good result because we struggled a bit this morning in the foursomes,” Fennelly said.
“The girls are extremely strong, and I expected a few of the top matches (to win) early this morning, and it didn’t happen, and the guys rallied really, really well.
“So to come back out fighting again and start fast, I think we had a really good session this afternoon here.
“Again, mixed foursomes is such a tough format for the players, playing something that most of them haven’t done and they’ve been absolutely superb.
“The energy, the commitment level has been fantastic so pretty happy. Like anything, you’ll always look at a few holes there – Hannah Darling and Phichaksn Maichon were in a great game, but they just stumbled towards the end.
“But listen, stuff like that at the last is just fantastic. An eagle finish by Wenyi Ding and Louise to tie it up, that’s great.
“You never want to be psychologically behind, so I think this is a pretty decent result. It’s so tight every day with the teams so well-matched, so we’ll take it and come out fighting tomorrow.
“Sara and Max have been sensational. They really rose to the occasion. But I’m gutted for Ryan and Kate.
“They battled back but got an awful lie left at the 18th and they were forced to lay up. But they have been fantastic, and it is all to play for tomorrow.”
Final Round ~ Singles Pairings
7:30 am (#1)
Michael La Sasso (United States) vs. Josele Ballester (International)
7:30 am (#10)
Jackson Van Paris (United States) vs. Calum Scott (International)
7:40 am (#1)
Jack Lundin (United States) vs. Filip Jakubcik (International)
7:40 am (#10)
Gordon Sargent (United States) vs. Bastien Amat (International)
7:50 am (#1)
Amanda Sambach (United States) vs. Adela Cernousek (International)
7:50 am (#10)
Mary Kelly Mulcahy (United States) vs. Kate Lanigan (International)
8:00 am (#1)
Maisie Filler (United States) vs. Hannah Darling (International)
8:00 am (#10)
Farah O’Keefe (United States) vs. Maria José Marin (International)
8:10 am (#1)
Rachel Kuehn (United States) vs. Louise Rydqvist (International)
8:10 am (#10)
Ian Gilligan (United States) vs. Omar Morales (International)
8:20 am (#1)
Jackson Klutznick (United States) vs. Santiago de la Fuente (International)
8:20 am (#10)
Anna Davis (United States) vs. Paula Martín Sampedro (International)
8:30 am (#1)
Melanie Green (United States) vs. Sara Byrne (International)
8:30 am (#10)
Brendan Valdes (United States) vs. Phichaksn Maichon (International)
8:40 am (#1)
Maxwell Ford (United States) vs. Ryan Griffin (International)
8:40 am (#10)
Kiara Romero (United States) vs. Emma Bunch (International)
8:50 am (#1)
Zoe Campos (United States) vs. Caitlyn Macnab (International)
8:50 am (#10)
David Ford (United States) vs. Ben van Wyk (International)
9:00 am (#1)
Ben James (United States) vs. Max Kennedy (International)
9:00 am (#10)
Catherine Park (United States) vs. Mirabel Ting (International)
9:10 am (#1)
Latanna Stone (United States) vs. Julia Lopez Ramirez (International)
9:10 am (#10)
Jackson Koivun (United States) vs. Wenyi Ding (International)
9:20 am (#1)
Preston Summerhays (United States) vs. Jacob Skov Olesen (International)
9:20 am (#10)
Anna Morgan (United States) vs. Carla Bernat (International)