Ireland Women lost by 154 runs to Bangladesh in the first one-day international in Mirpur.
After winning the toss and opting to bat, the home side amassed 252 for four from their 50 overs.
Sharmin Akhter fell four runs short of a century while opener Fargana Hoque scored 61 as Bangladesh posted a strong total.
Ireland never came close in their reply, losing wickets regularly, including two in successive balls to Marufa Akter in the third over that set the tone.
Only three batters made it into double figures, with Sarah Forbes top-scoring with 25, and Ireland were all out for only 98 inside 30 overs.
The second ODI of the three-match series takes place on Saturday.
As well as three ODI games, Ireland will also take on Bangladesh in three T20 encounters.
The ODIs will form part of the ICC Women’s Championship which leads to World Cup qualification.
The Women’s Championship consists of 10 teams with hosts India and five other countries automatically qualifying for the World Cup in 2025, with Ireland currently bottom of the group with three wins from 18 games.
The Irish will wrap up their series against India in January before heading to the final qualifiers next March.